NASDAQ · Biotechnology

RYTM (RYTM) Stock

$110.01 +3.65% NASDAQ: RYTM Healthcare

Valuation

MetricValue
Price$110.01
Market Cap$7.55B
P/E Ratio-28.04
P/B Ratio43.00
P/S Ratio31.46
EPS (TTM)$-3.11
52-Week High$122.20
52-Week Low$60.80
Dividend Yield—

Financials & Margins

MetricValue
ROE-141.73%
ROA-40.96%
ROCE-138.13%
Gross Margin-101.05%
Operating Margin-101.05%
Net Margin-103.68%
Debt/Equity1.77
Current Ratio4.41

Annual Financials (USD)

Metric20212022202320242025
Revenue$3.0M$24.0M$77.0M$130.0M$190.0M
Operating Profit$-170.0M$-179.0M$-184.0M$-266.0M$-192.0M
Net Profit$-70.0M$-181.0M$-185.0M$-261.0M$-197.0M
EPS$-1.37$-3.51$-3.20$-4.34$-3.11
Op Margin-5391.9%-757.9%-238.1%-204.0%-101.2%

Balance Sheet (USD)

Metric20212022202320242025
Total Assets$330.0M$382.0M$333.0M$392.0M$481.0M
Total Liabilities$45.0M$118.0M$163.0M$228.0M$342.0M
Cash$59.0M$128.0M$60.0M$89.0M$54.0M
Borrowings$3.0M$2.0M$1.0M$4.0M$246.0M

Latest News

Rhythm Pharmaceuticals Announces The New England Journal of Medicine Publication of Phase 3 TRANSCEND Trial Results in Acquired Hypothalamic Obesity GlobeNewswire · Jul 8, 2026 Is Rhythm Pharmaceuticals, Inc. (RYTM) Stock Poised for Growth After Encouraging Setmelanotide Trial Results? Insider Monkey · Jun 30, 2026 Strength Seen in Acadia (ACAD): Can Its 6.8% Jump Turn into More Strength? Zacks · Jun 29, 2026 Intel Stock and 3 Other Winners I Found Using Barchart’s High-Octane Stock Screener Barchart · Jun 22, 2026 Can Rhythm Pharmaceuticals (RYTM) ’s New Data Help Patients With a Rare Hunger Disorder? Insider Monkey · Jun 22, 2026

Cash Flow (USD)

Metric20212022202320242025
Operating Cash Flow$-146.0M$-173.0M$-136.0M$-114.0M$-116.0M
Investing Cash Flow$-68.0M$24.0M$-6.0M$-48.0M$-138.0M
Financing Cash Flow$5.0M$83.0M$25.0M$13.0M$-20.0M
Net Cash Flow$-42.0M$68.0M$-68.0M$29.0M$-35.0M
Free Cash Flow$-151.0M$-178.0M$-136.0M$-114.0M$-117.0M

Valuation & Return Ratios

MetricValue
PEG Ratio—
EV / EBITDA—
FCF Yield-1.96%
Quick Ratio4.16
Interest Coverage-9.14
Return 1Y20.28%
Return 3Y509.14%
Return 5Y449.77%

Ownership

Insiders Held0.77%
Institutions Held110.22%
Institutions Float Held111.07%
Institutional HolderSharesReport Date
RA Capital Management, L.P.6,666,8372026-03-31
Blackrock Inc.6,237,1512026-03-31
Baker Bros. Advisors, LP5,604,4832026-03-31
Primecap Management Company3,417,5092026-03-31
Vanguard Portfolio Management LLC3,040,7182026-03-31

Peer Comparison

TickerPriceChangeP/EMarket CapDiv Yield
ACLXArcellx, Inc. $115.07 +0.02% -28.27 $6.73B 0.00%
AKROAkero Therapeutics, Inc. $54.65 +0.00% -19.87 $4.50B 0.00%
ARVN $8.02 -3.43% -6.94 $517.14M 0.00%
BDTX $1.76 +1.45% -1.48 $100.56M 0.00%
CGEM $17.21 -1.49% -3.76 $1.06B 0.00%

About RYTM

RYTM is led by CEO David Meeker, employs 414 people, headquartered in Boston, US, publicly traded since 2017.

RYTM stock trades at $110.01 with a market capitalization of $7.55B. The stock is valued at a price-to-earnings (P/E) ratio of -28.04, price-to-book of 43.00, price-to-sales of 31.46. Over the past 52 weeks the stock has ranged between $60.80 and $122.20, and currently trades 10.0% below its 52-week high.

On profitability, RYTM generates a return on equity (ROE) of -141.73%, return on capital employed of -138.13%, an operating margin of -101.05%, a net profit margin of -103.68%.

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