What is Opko Health, Inc. (OPK) stock price today?

Opko Health, Inc. (OPK) is currently trading at $1.38, up 0.73% today.

What is OPK P/E ratio?

Opko Health, Inc.'s P/E ratio is -16.37. This is below the market average, suggesting the stock may be undervalued relative to earnings.

What is OPK return on equity (ROE)?

Opko Health, Inc.'s return on equity (ROE) is -5.88%, indicating how efficiently the company generates profit from shareholders' equity. This is below the typical market average of 12-15%.

What is Opko Health, Inc.'s market cap?

Opko Health, Inc. has a market capitalization of $1.03B.

NASDAQ · Medical - Diagnostics & Research

Opko Health, Inc. (OPK) Stock

$1.38 +0.73% NASDAQ: OPK Healthcare

Valuation

Metric	Value
Price	$1.38
Market Cap	$1.03B
P/E Ratio	-16.37
P/B Ratio	0.99
P/S Ratio	1.98
EPS (TTM)	$-0.30
52-Week High	$1.75
52-Week Low	$0.98
Dividend Yield	0.00%

Financials & Margins

Metric	Value
ROE	-5.88%
ROA	-3.98%
ROCE	-8.92%
Gross Margin	-36.08%
Operating Margin	-36.08%
Net Margin	-12.40%
Debt/Equity	0.33
Current Ratio	3.96

Annual Financials (USD)

Metric	2021	2022	2023	2024	2025
Revenue	$1.8B	$1.0B	$863.0M	$713.0M	$607.0M
Operating Profit	$19.0M	$-226.0M	$-157.0M	$-152.0M	$-219.0M
Net Profit	$-30.0M	$-328.0M	$-189.0M	$-53.0M	$-226.0M
EPS	$-0.05	$-0.46	$-0.25	$-0.08	$-0.30
Op Margin	1.1%	-22.5%	-18.2%	-21.3%	-36.1%

Balance Sheet (USD)

Metric	2021	2022	2023	2024	2025
Total Assets	$2.4B	$2.2B	$2.0B	$2.2B	$1.9B
Total Liabilities	$715.0M	$606.0M	$622.0M	$835.0M	$664.0M
Cash	$135.0M	$153.0M	$96.0M	$432.0M	$369.0M
Borrowings	$255.0M	$306.0M	$327.0M	$504.0M	$434.0M

Latest News

Entera Reports Robust Preclinical Data for EB612 (Oral LA-PTH(1-34)) for Hypoparathyroidism and EB618 (Oral GLP-1/Glucagon) for Obesity at ENDO 2026 GlobeNewswire · Jun 16, 2026 Preclinical Data for OPKO Biologics' OPK8801001 in Acromegaly Presented at ENDO 2026 GlobeNewswire · Jun 15, 2026 Discover 3 Promising Penny Stocks With Market Caps Over $20M Simply Wall St. · Jun 9, 2026 Assessing OPKO Health (OPK) Valuation After Expanded Nicoya RAYALDEE Partnership In Greater China Simply Wall St. · Jun 7, 2026 How Investors May Respond To OPKO Health (OPK) Boosting Its Nicoya Stake And RAYALDEE Milestones Simply Wall St. · Jun 7, 2026

Cash Flow (USD)

Metric	2021	2022	2023	2024	2025
Operating Cash Flow	$38.0M	$-95.0M	$-28.0M	$-183.0M	$-179.0M
Investing Cash Flow	$4.0M	$66.0M	$-34.0M	$327.0M	$218.0M
Financing Cash Flow	$0	$0	$0	$-104.0M	$-47.0M
Net Cash Flow	$62.0M	$18.0M	$-57.0M	$350.0M	$-63.0M
Free Cash Flow	$6.0M	$-120.0M	$-44.0M	$-208.0M	$-191.0M

Valuation & Return Ratios

Metric	Value
PEG Ratio	-0.61
EV / EBITDA	27.02
FCF Yield	-11.51%
Quick Ratio	2.93
Interest Coverage	-3.33
Return 1Y	-18.18%
Return 3Y	-36.41%
Return 5Y	-65.54%

Ownership

Insiders Held49.95%

Institutions Held27.01%

Institutions Float Held53.97%

Institutional Holder	Shares	Report Date
Rubric Capital Management LP	47,791,243	2026-03-31
Blackrock Inc.	36,232,223	2026-03-31
Vanguard Portfolio Management LLC	14,769,719	2026-03-31
Vanguard Capital Management LLC	14,499,164	2026-03-31
Geode Capital Management, LLC	11,301,501	2026-03-31

Peer Comparison

Ticker	Price	Change	P/E	Market Cap	Div Yield
BLLNBillionToOne, Inc.	$98.09	+2.81%	154.24	$4.51B	0.00%
CSTLCastle Biosciences, Inc.	$34.42	+2.11%	-53.92	$1.05B	0.00%
FLGTFulgent Genetics, Inc.	$21.74	+4.42%	-7.62	$617.43M	0.00%
GHGuardant Health, Inc.	$167.47	+1.15%	-48.23	$22.47B	0.00%
MDXHMDxHealth SA	$0.59	+1.58%	-1.02	$30.29M	0.00%

About Opko Health, Inc.

Opko Health, Inc. is led by CEO Phillip Frost, publicly traded since 1995.

Opko Health, Inc. (OPK) stock trades at $1.38 with a market capitalization of $1.03B. The stock is valued at a price-to-earnings (P/E) ratio of -16.37, price-to-book of 0.99, price-to-sales of 1.98. Over the past 52 weeks the stock has ranged between $0.98 and $1.75, and currently trades 21.1% below its 52-week high.

On profitability, Opko Health, Inc. generates a return on equity (ROE) of -5.88%, return on capital employed of -8.92%, an operating margin of -36.08%, a net profit margin of -12.40%.

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