OTC · Drug Manufacturers - General

Ono Pharmaceutical Co., Ltd. (OPHLY) Stock

$4.85 -0.19% OTC: OPHLY Healthcare

Ono Pharmaceutical Co., Ltd., along with its subsidiaries, operates globally, engaging in the research, development, procurement, and commercialization of pharmaceutical products and diagnostic reagents. Its current portfolio features a range of established treatments, notably in oncology, with products such as the intravenous infusions OPDIVO and KYPROLIS, alongside MEKTOVI, VELEXBRU, ADLUMIZ (tablets), and BRAFTOVI (capsules) for various malignant tumors.

Valuation

MetricValue
Price$4.85
Market Cap$6.84B
P/E Ratio16.20
P/B Ratio1.33
P/S Ratio2.19
EPS (TTM)$0.30
52-Week High$5.75
52-Week Low$3.55
Dividend Yield2.06%

Financials & Margins

MetricValue
ROE8.54%
ROA6.31%
ROCE10.96%
Gross Margin72.52%
Operating Margin20.03%
Net Margin13.53%
Debt/Equity0.14
Current Ratio2.86

Annual Financials (USD)

Metric20222023202420252026
Revenue$361.4B$447.2B$502.7B$486.9B$546.9B
Operating Profit$103.2B$142.0B$163.1B$59.7B$109.6B
Net Profit$80.5B$112.7B$128.0B$50.0B$74.0B
EPS$54.05$76.92$88.87$35.47$52.73
Op Margin28.6%31.8%32.5%12.3%20.0%

Balance Sheet (USD)

Metric20222023202420252026
Total Assets$739.2B$882.4B$913.7B$1.06T$1.11T
Total Liabilities$77.5B$134.6B$115.1B$275.8B$251.0B
Cash$69.1B$96.1B$166.1B$204.6B$238.1B
Borrowings$8.8B$9.2B$8.9B$146.7B$121.5B

Latest News

Should Value Investors Buy Ono Pharmaceutical Co. (OPHLF) Stock? Zacks · Jul 13, 2026 Ono Pharmaceutical Co. (OPHLF) Moves 10.4% Higher: Will This Strength Last? Zacks · Jul 7, 2026 Deciphera Pharmaceuticals Announces First Patient Dosed in Pivotal Phase 3 INTREPID Study of Sapablursen in Polycythemia Vera Business Wire · Jun 17, 2026 Thyroid Cancer (TC) Market View Report 2026: Ipsen/Exelixis, Ono Pharmaceutical, and Novartis Dominate the Treatment Landscape GlobeNewswire · May 6, 2026

Cash Flow (USD)

Metric20222023202420252026
Operating Cash Flow$61.8B$159.6B$110.7B$82.5B$145.1B
Investing Cash Flow$-6.2B$-114.8B$27.3B$-144.8B$-48.7B
Financing Cash Flow$-32.6B$-2.7B$-52.7B$-3.2B$-3.6B
Net Cash Flow$8.1B$27.0B$70.0B$38.4B$19.5B
Free Cash Flow$49.6B$145.1B$89.8B$74.5B$138.7B

Valuation & Return Ratios

MetricValue
PEG Ratio0.41
EV / EBITDA7.57
FCF Yield11.57%
Quick Ratio2.51
Interest Coverage29.20
Return 1Y35.85%
Return 3Y-15.95%
Return 5Y-33.21%

Ownership

Insiders Held0.00%
Institutions Held0.01%
Institutions Float Held0.01%
Institutional HolderSharesReport Date
First Command Advisory Services, Inc.1,7462026-03-31
Salomon & Ludwin, LLC312026-03-31
Rhumbline Advisers5,5752026-03-31
Gamma Investing LLC45,5272026-06-30
Fulton Bank, NA13,6042026-06-30

Peer Comparison

TickerPriceChangeP/EMarket CapDiv Yield
DSRLFDiaSorin S.p.A. $79.99 +3.11% 25.87 $3.96B 1.89%
FLMNFFielmann AG $50.75 +0.00% 15.87 $4.26B 3.15%
GZPHFGuangzhou Baiyunshan Pharmaceutical Holdings Company Limited $2.34 +0.00% 12.06 $6.20B 5.56%
HKMPFHikma Pharmaceuticals PLC $20.37 +0.00% 0.19 $4.29B 4.71%
HKMPYHikma Pharmaceuticals PLC $42.02 +1.93% 0.19 $4.40B 4.57%

About Ono Pharmaceutical Co., Ltd.

Ono Pharmaceutical Co., Ltd., along with its subsidiaries, operates globally, engaging in the research, development, procurement, and commercialization of pharmaceutical products and diagnostic reagents. Its current portfolio features a range of established treatments, notably in oncology, with products such as the intravenous infusions OPDIVO and KYPROLIS, alongside MEKTOVI, VELEXBRU, ADLUMIZ (tablets), and BRAFTOVI (capsules) for various malignant tumors. Other specialized oncology support includes EMEND capsules and PROEMEND intravenous injections to manage chemotherapy-induced nausea and vomiting, and DEMSER capsules for symptomatic improvement in pheochromocytoma patients. Beyond cancer, Ono offers therapies for prevalent conditions like type 2 diabetes (GLACTIV and FORXIGA tablets), chronic heart failure (CORALAN), and various inflammatory and neurological disorders. Specific offerings in these areas include ONOACT injections for tachyarrhythmia, OPALMON tablets for peripheral circulatory issues, ORENCIA injections for rheumatoid arthritis, RIVASTACH patches for Alzheimer's disease, and ONGENTYS tablets for Parkinson's disease. The company also addresses needs in renal care with PARSABIV intravenous injections for dialysis patients, urological health with STAYBLA tablets for overactive bladder, and respiratory conditions with ONON capsules and dry syrups for bronchial asthma and allergic rhinitis. Furthermore, its offerings extend to musculoskeletal health with JOYCLU intra-articular injections for improving joint function, and RECALBON tablets for osteoporosis. Ono Pharmaceutical is also deeply invested in future medical advancements, with an extensive pipeline of products under development. This pipeline targets a wide array of diseases, encompassing numerous types of cancer, including esophageal, urothelial carcinoma, Hodgkin's lymphoma, ovarian, bladder, prostate, hepatocellular carcinoma, pancreatic, biliary tract, gastric, thyroid, colorectal, melanoma, acute myeloid leukemia, non-small cell lung cancer, primary central nervous system lymphoma, and myelodysplastic syndrome, as well as addressing virus positive/negative solid carcinoma. Beyond oncology, their research extends to inflammatory and autoimmune disorders such as polymyositis/dermatomyositis, pemphigus, generalized scleroderma, and enthesopathy. They are also developing treatments for conditions affecting the cardiovascular and nervous systems, including tachyarrhythmia, diabetic polyneuropathy, neurodegenerative diseases, narcolepsy, and thrombosis. Established in 1717, Ono Pharmaceutical Co., Ltd. maintains its headquarters in Osaka, Japan.

Ono Pharmaceutical Co., Ltd. is headquartered in JP.

Ono Pharmaceutical Co., Ltd. (OPHLY) stock trades at $4.85 with a market capitalization of $6.84B. The stock is valued at a price-to-earnings (P/E) ratio of 16.20, price-to-book of 1.33, price-to-sales of 2.19. Over the past 52 weeks the stock has ranged between $3.55 and $5.75, and currently trades 15.7% below its 52-week high. It pays a dividend yielding 2.06%.

On profitability, Ono Pharmaceutical Co., Ltd. generates a return on equity (ROE) of 8.54%, return on capital employed of 10.96%, an operating margin of 20.03%, a net profit margin of 13.53%.

Official website: www.ono-pharma.com

Related Healthcare Stocks

LLY Drug Manufacturers - General $1185.71 -0.52% JNJ Drug Manufacturers - General $259.24 +0.88% ABBV Drug Manufacturers - General $246.04 +0.89% UNH Medical - Healthcare Plans $407.08 +0.77% MRK Drug Manufacturers - General $128.57 +0.16% NVS Drug Manufacturers - General $158.83 -0.64% NVO Biotechnology $51.58 +1.22% TMO Medical - Diagnostics & Research $594.00 +2.41% AMGN Drug Manufacturers - General $387.64 -1.39% ABT Medical - Devices $108.03 +0.70% GILD Drug Manufacturers - General $132.73 -1.18% PFE Drug Manufacturers - General $26.74 +2.06%

Popular Stocks

Apple (AAPL)Microsoft (MSFT)NVIDIA (NVDA)Alphabet (GOOGL)Amazon (AMZN)Meta (META)Tesla (TSLA)Broadcom (AVGO)JPMorgan (JPM)Visa (V)

Screens featuring this stock

High ROE Healthcare StocksLow P/E Healthcare StocksHigh Net Margin Healthcare StocksDividend Healthcare StocksLow Debt Healthcare StocksAll stock screens
Run Stock Screener Investing Guides