OTC · Drug Manufacturers - General

Ono Pharmaceutical Co., Ltd. (OPHLF) Stock

$13.38 +0.00% OTC: OPHLF Healthcare

Globally, Ono Pharmaceutical Co., Ltd., along with its affiliated entities, is engaged in the development, procurement, and commercialization of pharmaceutical products and diagnostic tools. Its product line features a wide array of therapeutic solutions, including several key oncology treatments such as OPDIVO, KYPROLIS, MEKTOVI, VELEXBRU, ADLUMIZ, and BRAFTOVI.

Valuation

MetricValue
Price$13.38
Market Cap$6.29B
P/E Ratio16.20
P/B Ratio1.33
P/S Ratio2.19
EPS (TTM)$0.83
52-Week High$18.67
52-Week Low$10.27
Dividend Yield3.66%

Financials & Margins

MetricValue
ROE8.54%
ROA6.31%
ROCE10.96%
Gross Margin72.52%
Operating Margin20.03%
Net Margin13.53%
Debt/Equity0.14
Current Ratio2.86

Annual Financials (USD)

Metric20222023202420252026
Revenue$361.4B$447.2B$502.7B$486.9B$519.0B
Operating Profit$114.9B$152.3B$163.1B$59.7B$104.0B
Net Profit$80.5B$112.7B$128.0B$50.0B$70.2B
EPS$162.16$230.79$266.60$106.41$148.60
Op Margin31.8%34.1%32.5%12.3%20.0%

Balance Sheet (USD)

Metric20222023202420252026
Total Assets$739.2B$882.4B$913.7B$1.06T$1.11T
Total Liabilities$77.5B$134.6B$115.1B$275.8B$251.4B
Cash$69.1B$96.1B$166.1B$204.6B$238.5B
Borrowings$8.8B$9.2B$8.9B$146.7B$121.7B

Latest News

Should Value Investors Buy Ono Pharmaceutical Co. (OPHLF) Stock? Zacks · Jul 13, 2026 Ono Pharmaceutical Co. (OPHLF) Moves 10.4% Higher: Will This Strength Last? Zacks · Jul 7, 2026 Deciphera Pharmaceuticals Announces First Patient Dosed in Pivotal Phase 3 INTREPID Study of Sapablursen in Polycythemia Vera Business Wire · Jun 17, 2026 Thyroid Cancer (TC) Market View Report 2026: Ipsen/Exelixis, Ono Pharmaceutical, and Novartis Dominate the Treatment Landscape GlobeNewswire · May 6, 2026

Cash Flow (USD)

Metric20222023202420252026
Operating Cash Flow$61.8B$159.6B$110.7B$82.5B$137.7B
Investing Cash Flow$-6.2B$-114.8B$27.3B$-144.8B$-46.2B
Financing Cash Flow$-32.6B$-2.7B$-52.7B$-3.2B$-3.4B
Net Cash Flow$8.1B$27.0B$70.0B$38.4B$20.7B
Free Cash Flow$49.6B$145.1B$89.8B$74.5B$131.6B

Valuation & Return Ratios

MetricValue
PEG Ratio0.41
EV / EBITDA7.57
FCF Yield11.57%
Quick Ratio2.51
Interest Coverage29.20
Return 1Y25.99%
Return 3Y
Return 5Y

Ownership

Insiders Held13.24%
Institutions Held40.47%
Institutions Float Held46.65%
Institutional HolderSharesReport Date
Pacer Advisors, Inc.215,6292025-09-30

Peer Comparison

TickerPriceChangeP/EMarket CapDiv Yield
AAPLApple Inc. $313.33 +0.29% 37.72 $4.60T 0.34%
MSFTMicrosoft Corporation $499.99 +0.03% 22.95 $3.71T 0.94%
GOOGLAlphabet Inc. $354.30 -0.96% 27.68 $4.29T 0.23%
AMZNAmazon.com, Inc. $274.48 +0.82% 28.76 $2.95T 0.00%
METAMeta Platforms, Inc. $592.10 +0.37% 21.47 $1.51T 0.35%

About Ono Pharmaceutical Co., Ltd.

Globally, Ono Pharmaceutical Co., Ltd., along with its affiliated entities, is engaged in the development, procurement, and commercialization of pharmaceutical products and diagnostic tools. Its product line features a wide array of therapeutic solutions, including several key oncology treatments such as OPDIVO, KYPROLIS, MEKTOVI, VELEXBRU, ADLUMIZ, and BRAFTOVI. It also offers EMEND and PROEMEND for managing chemotherapy-induced nausea and vomiting, and DEMSER for pheochromocytoma symptoms. For metabolic health, GLACTIV and FORXIGA target type 2 diabetes. The company provides medications for cardiovascular conditions (ONOACT for tachyarrhythmia, OPALMON for peripheral circulatory disorder, CORALAN for chronic heart failure) and autoimmune diseases (ORENCIA for rheumatoid arthritis). Neurological disorders are addressed with RIVASTACH for Alzheimer's and ONGENTYS for Parkinson's disease. Other significant offerings cover conditions such as overactive bladder (STAYBLA), bronchial asthma and allergic rhinitis (ONON), osteoporosis (RECALBON), and joint function improvement (JOYCLU), alongside PARSABIV for dialysis patients. Beyond its existing portfolio, the company maintains an active research and development pipeline, focusing on numerous therapeutic areas. This includes a broad spectrum of oncological conditions, such as various carcinomas (esophageal, urothelial, ovarian, bladder, prostate, hepatocellular, pancreatic, biliary tract, gastric, thyroid, colorectal, non-small cell lung), lymphomas (Hodgkin's, primary central nervous system), melanoma, acute myeloid leukemia, myelodysplastic syndrome, and virus-positive/negative solid tumors. Its developmental efforts also extend to inflammatory and autoimmune disorders like polymyositis/dermatomyositis, pemphigus, generalized scleroderma, and enthesopathy, as well as cardiovascular issues (tachyarrhythmia, thrombosis), neurodegenerative diseases, diabetic polyneuropathy, and conditions such as narcolepsy. Established in 1717, this long-standing enterprise operates from its main office in Osaka, Japan.

Ono Pharmaceutical Co., Ltd. is headquartered in JP.

Ono Pharmaceutical Co., Ltd. (OPHLF) stock trades at $13.38 with a market capitalization of $6.29B. The stock is valued at a price-to-earnings (P/E) ratio of 16.20, price-to-book of 1.33, price-to-sales of 2.19. Over the past 52 weeks the stock has ranged between $10.27 and $18.67, and currently trades 28.3% below its 52-week high. It pays a dividend yielding 3.66%.

On profitability, Ono Pharmaceutical Co., Ltd. generates a return on equity (ROE) of 8.54%, return on capital employed of 10.96%, an operating margin of 20.03%, a net profit margin of 13.53%.

Official website: www.ono-pharma.com

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