NASDAQ · Biotechnology

IONS (IONS) Stock

$54.37 -2.84% NASDAQ: IONS Healthcare

Valuation

MetricValue
Price$54.37
Market Cap$8.99B
P/E Ratio-41.80
P/B Ratio27.91
P/S Ratio12.99
EPS (TTM)$-2.38
52-Week High$86.74
52-Week Low$40.03
Dividend Yield0.00%

Financials & Margins

MetricValue
ROE-58.57%
ROA-9.47%
ROCE-12.91%
Gross Margin98.35%
Operating Margin-33.35%
Net Margin-30.87%
Debt/Equity4.15
Current Ratio4.10

Annual Financials (USD)

Metric20212022202320242025
Revenue$810.0M$587.0M$788.0M$705.0M$944.0M
Operating Profit$-30.0M$-410.0M$-354.0M$-475.0M$-382.0M
Net Profit$-29.0M$-270.0M$-366.0M$-454.0M$-381.0M
EPS$-0.20$-1.90$-2.56$-3.04$-2.38
Op Margin-3.7%-69.8%-44.9%-67.4%-40.5%

Balance Sheet (USD)

Metric20212022202320242025
Total Assets$2.6B$2.5B$3.0B$3.0B$3.5B
Total Liabilities$1.8B$2.0B$2.6B$2.4B$3.0B
Cash$869.0M$276.0M$399.0M$242.0M$372.0M
Borrowings$1.3B$1.4B$1.5B$1.4B$2.6B

Latest News

Why Arrowhead Shot Sky-High, While Chief Rival Ionis Toppled Investor's Business Daily · Jul 22, 2026 Earnings Preview: Ionis Pharmaceuticals (IONS) Q2 Earnings Expected to Decline Zacks · Jul 22, 2026 Cathie Wood Just Bet Big on This Biotech Stock Motley Fool · Jul 18, 2026 Ionis to hold second quarter 2026 financial results webcast Business Wire · Jul 15, 2026 Biogen Slumps As Alzheimer's Study Leaves 'More Questions Than Answers' Investor's Business Daily · Jul 14, 2026

Cash Flow (USD)

Metric20212022202320242025
Operating Cash Flow$31.0M$-274.0M$-308.0M$-501.0M$-269.0M
Investing Cash Flow$177.0M$-283.0M$-242.0M$-179.0M$-329.0M
Financing Cash Flow$-153.0M$-11.0M$508.0M$0$0
Net Cash Flow$472.0M$-593.0M$123.0M$-157.0M$130.0M
Free Cash Flow$13.0M$-294.0M$-336.0M$-546.0M$-320.0M

Valuation & Return Ratios

MetricValue
PEG Ratio7.80
EV / EBITDA3.40
FCF Yield-7.07%
Quick Ratio4.09
Interest Coverage-3.92
Return 1Y28.50%
Return 3Y31.34%
Return 5Y42.41%

Peer Comparison

TickerPriceChangeP/EMarket CapDiv Yield
ASNDAscendis Pharma A/S $243.45 -0.19% 25.59 $15.12B 0.00%
BBIOBridgeBio Pharma, Inc. $85.33 +1.56% -22.41 $16.71B 0.00%
BMRN $60.00 -0.04% 41.31 $11.60B 0.00%
EXELExelixis, Inc. $55.96 +0.27% 16.38 $14.07B 0.00%
GHGuardant Health, Inc. $145.13 -1.49% -43.46 $19.24B 0.00%

About IONS

IONS is led by CEO Brett Monia, employs 1,402 people, headquartered in Carlsbad, US, publicly traded since 1991.

IONS stock trades at $54.37 with a market capitalization of $8.99B. The stock is valued at a price-to-earnings (P/E) ratio of -41.80, price-to-book of 27.91, price-to-sales of 12.99. Over the past 52 weeks the stock has ranged between $40.03 and $86.74, and currently trades 37.3% below its 52-week high.

On profitability, IONS generates a return on equity (ROE) of -58.57%, return on capital employed of -12.91%, an operating margin of -33.35%, a net profit margin of -30.87%.

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