Apellis Pharmaceuticals, Inc. (APLS) Stock

About Apellis Pharmaceuticals, Inc.

Apellis Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the discovery, development, and commercialization of novel therapeutic compounds to treat diseases with high unmet needs. It offers EMPAVELI for the treatment of paroxysmal nocturnal hemoglobinuria; and SYFOVRE for treating geographic atrophy secondary to age-related macular degeneration and geographic atrophy (GA). The company also develops EMPAVELI to treat C3 glomerulopathy and immune complex membranoproliferative glomerulonephritis, focal segmental glomerulosclerosis, and delayed graft function; and APL-3007, a small interfering RNA, or siRNA for the treatment of GA. In addition, it conducts preclinical studies for APL-9099, a treatment targeting the neonatal Fc receptor, or FcRn, which has the potential to be a first-in-class gene editing treatment for future target indications with one-time dosing; and developing other programs with its proprietary in-house capabilities and under its Beam collaboration. It has a collaboration and license agreement with Swedish Orphan Biovitrum AB (publ) for development and commercialization of pegcetacoplan; and a collaboration with Beam Therapeutics, Inc. focused on the use of Beam's base editing technology to discover new treatments for complement-driven diseases. Apellis Pharmaceuticals, Inc. was incorporated in 2009 and is headquartered in Waltham, Massachusetts. As of May 14, 2026, Apellis Pharmaceuticals, Inc. operates as a subsidiary of Biogen Inc.

Apellis Pharmaceuticals, Inc. (APLS) stock trades at $41.03 with a market capitalization of $5.25B. The stock is valued at a price-to-earnings (P/E) ratio of 38.37, price-to-book of 12.66, price-to-sales of 4.75. Over the past 52 weeks the stock has ranged between $16.10 and $41.14, and currently trades at its 52-week high.

On profitability, Apellis Pharmaceuticals, Inc. generates a return on equity (ROE) of 46.02% — well above the market average, a sign of a high-quality business, return on capital employed of 14.86%, an operating margin of 9.87%, a net profit margin of 12.06%.