NASDAQ · Biotechnology

SYRE (SYRE) Stock

$97.87 -2.09% NASDAQ: SYRE Healthcare

Valuation

MetricValue
Price$97.87
Market Cap$8.50B
P/E Ratio-33.65
P/B Ratio5.63
P/S Ratio44.47
EPS (TTM)$-1.98
52-Week High$104.48
52-Week Low$14.00
Dividend Yield0.00%

Financials & Margins

MetricValue
ROE-21.68%
ROA-19.92%
ROCE-29.37%
Gross Margin0.00%
Operating Margin-2.56%
Net Margin-1.98%
Debt/Equity0.00
Current Ratio13.19

Annual Financials (USD)

Metric20212022202320242025
Revenue$19.0M$2.0M$1.0M$0$0
Operating Profit$-66.0M$-85.0M$-242.0M$-209.0M$-210.0M
Net Profit$-66.0M$-84.0M$-339.0M$-208.0M$-155.0M
EPS$-25.02$-24.86$-46.15$-3.18$-1.98
Op Margin-350.3%-3640.2%-27348.0%——

Balance Sheet (USD)

Metric20212022202320242025
Total Assets$110.0M$71.0M$342.0M$608.0M$778.0M
Total Liabilities$26.0M$21.0M$158.0M$91.0M$63.0M
Cash$15.0M$35.0M$189.0M$89.0M$86.0M
Borrowings$5.0M$5.0M$0$0$0

Latest News

Mizuho Raises Price Target on Spyre Therapeutics to $120 From $84, Keeps Outperform Rating MT Newswires · Jul 13, 2026 Spyre Therapeutics Insider Sold Shares Worth $1,315,346, According to a Recent SEC Filing MT Newswires · Jul 6, 2026 Spyre Therapeutics Announces Grants of Inducement Awards GlobeNewswire · Jul 2, 2026 Spyre Therapeutics Stock Outlook Hinges on 2026 Study Catalysts Zacks · Jun 29, 2026 Spyre Therapeutics Insider Sold Shares Worth $1,307,000, According to a Recent SEC Filing MT Newswires · Jun 29, 2026

Cash Flow (USD)

Metric20212022202320242025
Operating Cash Flow$-54.0M$-80.0M$-100.0M$-157.0M$-169.0M
Investing Cash Flow$-23.0M$57.0M$-108.0M$-353.0M$-143.0M
Financing Cash Flow$2.0M$0$-5.0M$6.0M$-5.0M
Net Cash Flow$-75.0M$19.0M$153.0M$-100.0M$-4.0M
Free Cash Flow$-54.0M$-80.0M$-100.0M$-157.0M$-169.0M

Valuation & Return Ratios

MetricValue
PEG Ratio—
EV / EBITDA—
FCF Yield-4.62%
Quick Ratio8.97
Interest Coverage—
Return 1Y528.13%
Return 3Y592.75%
Return 5Y-37.76%

Ownership

Insiders Held5.86%
Institutions Held93.35%
Institutions Float Held99.16%
Institutional HolderSharesReport Date
FMR, LLC11,781,0242026-03-31
Blackrock Inc.5,521,2212026-03-31
RTW Investments LP4,171,9962026-03-31
Fairmount Funds Management LLC4,018,1012026-03-31
Perceptive Advisors Llc3,783,2252026-03-31

Peer Comparison

TickerPriceChangeP/EMarket CapDiv Yield
AAPLApple Inc. $313.33 +0.29% 37.72 $4.60T 0.34%
MSFTMicrosoft Corporation $499.99 +0.03% 22.95 $3.71T 0.94%
GOOGLAlphabet Inc. $354.30 -0.96% 27.68 $4.29T 0.23%
AMZNAmazon.com, Inc. $274.48 +0.82% 28.76 $2.95T 0.00%
METAMeta Platforms, Inc. $592.10 +0.37% 21.47 $1.51T 0.35%

About SYRE

SYRE is led by CEO Cameron Turtle, employs 112 people, headquartered in Waltham, US, publicly traded since 2016.

SYRE stock trades at $97.87 with a market capitalization of $8.50B. The stock is valued at a price-to-earnings (P/E) ratio of -33.65, price-to-book of 5.63, price-to-sales of 44.47. Over the past 52 weeks the stock has ranged between $14.00 and $104.48, and currently trades 6.3% below its 52-week high.

On profitability, SYRE generates a return on equity (ROE) of -21.68%, return on capital employed of -29.37%, an operating margin of -2.56%, a net profit margin of -1.98%.

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