NASDAQ · Biotechnology

Orchestra BioMed Holdings, Inc. (OBIO) Stock

$5.95 +3.84% NASDAQ: OBIO Healthcare

Valuation

MetricValue
Price$5.95
Market Cap$356.29M
P/E Ratio-6.01
P/B Ratio12.91
P/S Ratio11.14
EPS (TTM)$-1.11
52-Week High$6.50
52-Week Low$2.20
Dividend Yield0.00%

Financials & Margins

MetricValue
ROE-125.93%
ROA-51.02%
ROCE-56.73%
Gross Margin-157.58%
Operating Margin-157.58%
Net Margin-184.60%
Debt/Equity2.41
Current Ratio6.35

Annual Financials (USD)

Metric20212022202320242025
Revenue$-1.0M$4.0M$3.0M$3.0M$33.0M
Operating Profit$-22.0M$-33.0M$-52.0M$-64.0M$-52.0M
Net Profit$-23.0M$-34.0M$-49.0M$-61.0M$-53.0M
EPS$-0.02$-1.32$-1.48$-1.66$-1.11
Op Margin2787.6%-924.3%-1866.2%-2437.5%-154.7%

Balance Sheet (USD)

Metric20212022202320242025
Total Assets$14.0M$96.0M$95.0M$76.0M$115.0M
Total Liabilities$85.0M$43.0M$27.0M$43.0M$51.0M
Cash$10.0M$20.0M$31.0M$22.0M$35.0M
Borrowings$6.0M$12.0M$2.0M$17.0M$16.0M

Latest News

Orchestra BioMed Joins Russell 3000® and Russell 2000® Indexes GlobeNewswire · Jun 29, 2026 Sidoti Events, LLC's June Small-Cap Virtual Conference ACCESS Newswire · Jun 16, 2026 Orchestra BioMed Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4) GlobeNewswire · Jun 2, 2026 Favourable Signals For Orchestra BioMed Holdings: Numerous Insiders Acquired Stock Simply Wall St. · May 21, 2026 Orchestra BioMed to Participate in the Jefferies Global Healthcare Conference GlobeNewswire · May 19, 2026

Cash Flow (USD)

Metric20212022202320242025
Operating Cash Flow$-19.0M$-29.0M$-46.0M$-51.0M$-49.0M
Investing Cash Flow$13.0M$-65.0M$11.0M$13.0M$-27.0M
Financing Cash Flow$0$-10.0M$57.0M$-1.0M$-2.0M
Net Cash Flow$-10.0M$10.0M$11.0M$-8.0M$12.0M
Free Cash Flow$-20.0M$-30.0M$-46.0M$-51.0M$-49.0M

Valuation & Return Ratios

MetricValue
PEG Ratio-0.10
EV / EBITDA-7.12
FCF Yield-16.59%
Quick Ratio8.24
Interest Coverage-27.63
Return 1Y14.11%
Return 3Y-50.00%
Return 5Y-63.28%

Ownership

Insiders Held24.57%
Institutions Held41.78%
Institutions Float Held55.38%
Institutional HolderSharesReport Date
RTW Investments LP8,306,0632026-03-31
Perceptive Advisors Llc5,037,9062026-03-31
Vanguard Capital Management LLC2,204,3192026-03-31
Alyeska Investment Group, L.p.1,000,0002026-03-31
Propel Bio Management, LLC896,7012026-03-31

Peer Comparison

TickerPriceChangeP/EMarket CapDiv Yield
AVTXAvalo Therapeutics, Inc. $13.65 +1.64% -3.16 $717.52M 0.00%
CRBUCaribou Biosciences, Inc. $0.46 -4.36% -1.13 $45.64M 0.00%
ENTAEnanta Pharmaceuticals, Inc. $12.50 +3.31% -5.32 $363.48M 0.00%
EPRXEupraxia Pharmaceuticals Inc. $7.46 -1.45% -7.10 $249.76M 0.00%
IVAInventiva S.A. $4.47 +1.59% -2.04 $232.36M 0.00%

About Orchestra BioMed Holdings, Inc.

Orchestra BioMed Holdings, Inc. is led by CEO David Hochman, publicly traded since 2020.

Orchestra BioMed Holdings, Inc. (OBIO) stock trades at $5.95 with a market capitalization of $356.29M. The stock is valued at a price-to-earnings (P/E) ratio of -6.01, price-to-book of 12.91, price-to-sales of 11.14. Over the past 52 weeks the stock has ranged between $2.20 and $6.50, and currently trades 8.5% below its 52-week high.

On profitability, Orchestra BioMed Holdings, Inc. generates a return on equity (ROE) of -125.93%, return on capital employed of -56.73%, an operating margin of -157.58%, a net profit margin of -184.60%.

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